Senior OT Infrastructure Engineer

Senior OT Infrastructure Engineer

Location: Monksland, Athlone

37.5 per week (Mon–Fri, 09:00–17:00, flexible)

Competitive salary and benefits

Opening date: 14/04/2026

Closing date: midnight 20/04/2026

The Senior OT Infrastructure Engineer is a key member of the AAMF Manufacturing Systems team, responsible for the design, reliability, cybersecurity and lifecycle management of GMP‑critical OT infrastructure. This includes DCS/PLC/SCADA systems, data historians, servers and networks that underpin drug product manufacturing.

Working at the interface of IT and Automation, the role ensures systems remain highly available, secure and compliant, while enabling digitalisation, analytics and AI initiatives aligned with Industry 4.0 and site strategy.

Accountabilities:

Own reliability, availability and performance of GMP‑critical OT systems and networks

Maintain OT systems in a validated, audit‑ready state (cGMP, GAMP, 21 CFR Part 11, data integrity)

Plan and implement patching, upgrades, preventative maintenance and obsolescence strategies

Lead OT cybersecurity controls including network segmentation, vulnerability management and incident response

Govern change control, risk assessments, IQ/OQ/PQ support, and deviation investigations

Manage backups, disaster recovery, redundancy and restore testing

Drive OT upgrade projects from design through validation and cutover

Manage third‑party vendors and system integrators

Support AVEVA PI data ingestion, data quality and infrastructure readiness for analytics and AI solutions

Collaborate with Automation, Manufacturing, QA, Global Security and IT

Support training, standardisation and OT maturity across the manufacturing network

Essential Skills & Experience:

• Proven experience in OT / industrial IT within GMP manufacturing environments
• Hands‑on experience with DCS/PLC/SCADA systems (DeltaV strongly preferred)
• Strong experience with AVEVA / OSIsoft PI and SQL Server in validated environments
• Expertise in OT infrastructure (VMware/Hyper‑V, Windows Server, backups, endpoint hardening)
• Industrial networking and protocols (VLANs, firewalls, OPC/OPC UA, Industrial Ethernet)
• OT cybersecurity implementation and vulnerability management
• Strong knowledge of cGMP, GAMP 5, change control and validation
• Proven ability to lead complex OT projects and manage vendors
• Excellent communication and technical leadership skills

Desirable Skills & Experience:

• Degree in Engineering, Computer Science or similar
• Experience with Siemens, Rockwell, BMS/HVAC, Kepware or AVEVA platforms
• Scripting (PowerShell) and cloud/analytics integration exposure
• OT/IT certifications (ISA/IEC 62443, GICSP, VMware, Microsoft)

At AstraZeneca’s Alexion Rare Disease unit, work connects directly to people living with rare and devastating conditions, turning advanced science into meaningful impact every day. Colleagues collaborate in an open, inclusive environment that blends the agility of a biotech with the reach and resources of a global biopharma, enabling bold ideas in digitalisation, AI and advanced manufacturing to move quickly from concept to reality. Learning is continuous, with opportunities to grow skills, broaden experience and contribute to pioneering therapies that address areas of high unmet need while staying grounded in integrity, transparency and ethical decision-making.

If this opportunity resonates, apply now to help shape the future of manufacturing for people living with rare diseases!

Date Posted

14-Apr-2026

Closing Date

20-Apr-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.