Executive Director, Portfolio Strategy & Business Development - OBU Strategy

Introduction to role:

Drive innovation and impact at AstraZeneca by leading strategy for our industry-leading oncology pipeline. Collaborate with R&D and the Oncology Business Unit (OBU) to shape and deliver cutting-edge therapies that improve patient outcomes and bring us closer to eradicating cancer.

Working with a team of experts across Oncology R&D and the Oncology Business Unit, responsible for creating and implementing strategies to deliver an industry-leading and innovative oncology pipeline that improves patient care and outcomes. Strategies will be multi-brand or brand agnostic and built through analyses, insights, innovative thinking and cross-functional teamwork. An opportunity for a motivated, collaborative data-driven leader to help AstraZeneca one day eradicate cancer as a cause of death. The role

includes people management responsibilities, overseeing a high-performing team and fostering a culture of collaboration, maintaining high-performance and accountability.

Accountabilities:

• Leads the development and implementation of Business Unit therapy area, multi-brand or brand-agnostic strategies that integrate into one company-wide oncology strategy built with counterparts in global franchises and oncology R&D

• Drives portfolio strategic initiatives that enhance AZ’s competitiveness and deliver sustainable growth

• Frequently engages with C-Suite level leaders (SET and SET-1) to provide disciplined insights-driven valuations and strategies

• Drives clarity and consistency across priority business processes in major governance forums. These include investment decisions, TA Strategy/Portfolio reviews and long range plans across the specific tumour portfolios

• Engages with Finance VPs to ensure robust assessment of value in annual impairment review (key audit process)

• Leads the portfolio team in delivery of the commercial analysis, business development valuations, forecasting, market research and insight generation to shape and deliver OBU priorities: R&D decisions, supply planning and TA scenario analysis – including leadership of other team members working across the OBU Strategy team. You will work closely with the tumor area heads in OBU Strategy to do this.

• Understanding and communication of complex study design, TPPs, CDP’s, combination approaches, competition, pricing, prioritization, and decision making considerations expected in the context of our competitors’ strategies

• Managing large investment requests and business development opportunity assessments with extreme confidentiality, quality and rigor for consistency in approach

• Influence with and without authority a large number of senior stakeholders (SET, SET-1, SET-2) across OBU and ORD and criss-crossing tumour and asset alignment meetings

• Monitor market trends, competitive dynamics, and emerging science to inform strategic planning and business development priorities.

• Support Head of OBU Strategy to coordinate, oversee and integrate all tumor into one portfolio strategy

• Collaborate closely with Corporate Development, Finance, and R&D to support deal negotiations and integration planning.

• Guide and direct team members at the director and associate director level

• Maintain trusted partnering, credibility and collaboration with clinical, commercial and strategy leaders

Essential Skills & Experience:

• Bachelor's degree

• 15 years of relevant industry experience (or MBA/PhD with 10 years of relevant experience)

• Extensive experience in oncology +/- haematology

• Strong consultative and communication skills

• A strong scientific background and strategic analytical skills

• Industry or consulting experience in pharmaceutical pipeline strategy (market assessment, competitor analysis, forecasting)

• Excellent analysis and fact-based decision-making

• Experience with data and/or a science research/bio-pharmaceutical environment

• Motivated by working in a fast-paced field with clear societal impact

• Understanding of general business and core marketing principles and application to future healthcare market challenges

• Familiar with the oncology drug development process and necessary strategic and commercial touch points

• Prior experience managing direct reports

• Able to influence without authority and establish and maintain credibility with senior audiences

• Resourceful, motivated, decisive and proactive; must be able to manage multiple priorities in a fast-growing organization

• Attention to detail while also a big picture thinker & communicator

• A critical thinker with experience of identifying and driving key projects and providing researched, verified, relevant information to leaders.

Desirable Skills & Experience:

• MBA or PhD with 10 years of relevant experience

• Experience of setting up short- and long-term strategic plans

• Understanding of clinical data and clinical trial design

• Experience in at least two major geographies (e.g. US, EU, Japan, China)

• Experience in cell therapy and/or radioconjugates

• Thorough understanding of regulatory and pricing dynamics in major markets

• Comfortable with AI and utilizing AI to support ethical and accurate analyses of data

The annual base pay for this position ranges from $270,222 - $405,332. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

05-Dec-2025

Closing Date

19-Dec-2025

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.