Translational Science Director Immunology Cell Therapy

Are you a visionary authority in translational science, with the ability to implement a successful strategy in accelerating the development of cellular therapies for patients with immune-mediated diseases? If you are passionate about transforming the treatment of immune-mediated diseases and making a profound impact on patients' lives, then AstraZeneca might be the place for you! Our ambition is to build an outstanding organization that accelerates the delivery of transformative cell therapies for patients with immune-mediated diseases. We are driven by courage, curiosity, and teamwork, making bold decisions driven by patient outcomes.

Accountabilities:

As a Translational Science Director, you will be responsible for the design and implementation of translational and biomarker objectives for cellular therapies for immune-mediated diseases. Your focus will be on ensuring effective collaborations between research and development, establishing strong target-to-disease connections, differentiating AZ cellular therapeutics, and driving translational understanding of clinical trial data. In this role, you will be the GPT translational lead on immunology programs, driving the biomarker and translational objectives in alignment with clinical development plans. You will oversee translational studies and deliverables with CROs and collaborators to support new and ongoing clinical studies as well as to enable our LCM strategy. You will be recognized as an authority in translational science and work on difficult drug projects and complex scientific problems, providing solutions that are highly innovative.

Essential Skills/Experience:

• PhD or MD-PhD degree required. Degree or training in Immunology preferred.
• 8 or more years of industry experience with at least 5 years of combined academic/industry experience in clinical development or translational science.
• Strong knowledge of the pathogenesis of immune mediated disease and the application of cellular, molecular technologies and models to drive program decisions, including those related to supporting value propositions.
• Experience in clinical biomarker development (assay development and validation) of T-cell therapy and/or other advanced therapeutic modalities for Phase 1 studies and beyond.
• Prior experience in BM, precision medicine, IND filings, and deliverables for CSRs and other regulatory filings.
• Proven ability to learn new information rapidly and effectively.
• Demonstrated experience in selecting and leading CROs for translational studies and biomarkers for clinical trials.
• Experience in the authoring of relevant sections regulatory documents.
• Understanding of the full drug development process and critical translational biology needs at each developmental stage.
• Detailed understanding of translational and clinical research methodology and biostatistics principles.
• Understanding of FDA, EMA, MHRA and ICH GCP guidelines.
• Attention to detail, strive to generate high-quality work, and sense of passion and urgency to achieve team and program goals.
• Demonstrated experience contributing to and leading complex clinical stage projects.
• Proven track record in delivering results.
• Outstanding verbal and written communication skills.
• Excellent analytical, problem solving and strategic planning skills.

At AstraZeneca, we are at the cutting-edge of science, rethinking the future of medicine. We work on ground-breaking medicine discovery and development from early to late stage, answering some of the most complex unmet patient needs. We are never complacent about scientific discovery and development. Here we are always pushing our productivity, searching for new knowledge and the next breakthrough. We fully embrace a safe space, exercising our freedom to discover and share. You're supported by the team where setbacks are seen as learning opportunities.

When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and daring world.

Take the lead to make a bigger impact! Here we need leadership at every level. Physicians who not only have expertise but also the ability to build a case, engage multiple partners, and communicate effectively with different audiences. With that kind of remit comes great responsibility and the chance to create a big impact. Join us and be a part of our journey in transforming lives with science!

Ready to make a greater impact? Apply now!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.