Director Translational Science Immunology Cell Therapy

Are you a visionary authority in translational science, with the ability to implement a strategy in accelerating the development of cellular therapies for patients with immune-mediated diseases? If you are passionate about transforming the treatment of immune-mediated diseases and making a profound impact on patients' lives, then AstraZeneca might be the place for you! Do you have a passion for science and meaningful clinical development experience in Immunology and CAR-T cell therapies? Do you possess both strategic and operational leadership skills? If so, we invite you to join us! We are currently seeking a Global Development Scientist Director to be based in Boston Seaport.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. We are more than one of the world’s leading pharmaceutical companies.

Immunology Cell Therapy

Our ambition is to build a premier organization that accelerates the delivery of ground-breaking cell therapies for patients with immune mediated diseases. It’s our vision that unites and encourages us. Cell therapies represent a evolution of how drugs are discovered, developed and manufactured, these advanced potentially curative cellular modalities require a development strategy to ensure their rapid availability to patients. With multiple autoimmune and inflammatory indications and clinical stage cell therapies in global development, we strive forward. Focusing on groundbreaking science with the latest technology to achieve breakthroughs. AZ is a place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes.

Responsibilities

As a Translational Science Director, you will be responsible for the design and implementation of translational and biomarker objectives for cellular therapies for immune-mediated diseases. Your focus will be on ensuring teamwork between research and development, establishing strong target-to-disease connections, differentiating AZ cellular therapeutics, and driving translational understanding of clinical trial data. In this role, you will be the GPT translational lead on immunology programs, driving the biomarker and translational objectives in alignment with clinical development plans. You will oversee translational studies and deliverables with CROs and collaborators to support new and ongoing clinical studies as well as to enable our LCM strategy. You will be recognized as an authority in translational science and work on difficult drug projects and complex scientific problems, providing solutions that are highly innovative.

Essential Skills/Experience:

• PhD or MD-PhD degree required, with training in Immunology preferred.
• 5 or more years of industry or combined academic and shown experience in clinical development or translational science.
• Solid understanding of the pathogenesis of immune mediated disease and the application of cellular, molecular technologies and models to drive program decisions, including those related to supporting value propositions.
• Experience in clinical biomarker development (assay development and validation) of T-cell therapy and/or other advanced therapeutic modalities for Phase 1 studies and beyond.
• Prior experience in BM, precision medicine, and IND filings.
• Proven track record to learn new information rapidly and effectively.
• Demonstrated experience in selecting and leading CROs for translational studies and biomarkers for clinical trials.
• Experience in the authoring of relevant sections regulatory documents.
• Understanding of the full drug development process.
• Detailed understanding of translational and clinical research methodology and biostatistics principles.
• Understanding of FDA, EMA, MHRA and ICH GCP guidelines.
• Attention to detail, strive to generate high-quality work, and sense of passion and urgency to achieve team and program goals.
• Demonstrated experience contributing to and leading complex clinical stage projects.
• Proven track record in delivering results.
• Outstanding verbal and written communication skills.
• Proficient in analytical thinking, problem solving and strategic planning.

When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and daring world.

Why AstraZeneca?

At AstraZeneca, we are driven by 'following the science'. We are a science-driven organization where innovation is backed by investment and ambitious decision-making. Here, your innovative discoveries will ultimately have the potential to reach billions of patients in need, all across the globe. We are a team of leading specialists, driven to pursue scientific knowledge. We see the bigger picture and know where we can make the biggest impact. We are never complacent about scientific discovery and development. Here we are always pushing our efficiency, searching for new knowledge and the next breakthrough.

Ready to make a greater impact? Apply now!