Senior Scientist, Clinical PBPK Modeling

Are you passionate about pharmacokinetics and translational modeling? As a Senior Scientist in Clinical PBPK Modeling, you will play a crucial role in advancing clinical drug development through innovative and quantitative approaches. You will conduct mechanistic PBPK using clinical data to support the development of drug candidates across various therapy areas. Additionally, you will have the opportunity to contribute to broader areas within Clinical Pharmacology & Quantitative Pharmacology (CPQP) based on your experience and interests.

Accountabilities:

- Utilize physiologically-based pharmacokinetic (PBPK) and translational modeling tools to enable clinical PK projections for drug-drug interactions (DDIs), pediatric and other specific populations, and other clinical development questions.
- Collaborate with Drug Metabolism and Pharmacokinetic (DMPK) Scientists and Clinical Pharmacology scientists to generate these mechanistic models.
- Validate the mechanistic models to the level of being able to be used in Regulatory submissions and to influence the design of clinical trials.
- Communicate clearly and effectively both internally and externally on topics related to PBPK clinical DDI and pediatric and other specific populations predictions.
- Keep up to date with emerging literature, modeling science, and regulatory expectations.

Essential Skills/Experience:

- Knowledge of pharmacokinetics and Model-Informed Drug Development (MIDD).
- Demonstrated broad translational development expertise and experience exemplified by 0-4 Years of drug development experience, with emphasis on PBPK modelling.
- Good knowledge in pharmacology, drug targets and core disease areas.
- Demonstrated ability to identify, develop and execute PBPK activities  at a project level.
- Good oral and written communication skills.
- Good knowledge of global regulatory, compliance, processes, standards and issues specific to PBPK.
- PhD degree preferred or equivalent (M.Sc./Pharm.D.) with relevant experience required.
- Relevant regulatory experience (written).
- Training and experience with PBPK and other relevant software (e.g., SimCYP, GastroPlus, PK-Sim, Phoenix WinNonlin).
- Fluency in spoken and written English language.

Desirable Skills/Experience:

- A reputation gained from scientific publishing in the field of DMPK/Clinical Pharmacology.
- Experience in early and late stage drug development.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. Here all doors are open, and every voice is heard. From working side-by-side with academia to innovating with biotech, we are forever expanding our horizons. By sharing and increasing our knowledge we are empowered to be the best we can be and accelerate progress.

Ready to make a difference? Apply now to join our team!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.