Scientist, Research Histologist
Scientist, Research Histologist
Responsibilities
Performend‑to‑endhistology processing of tumor and normal tissues from mouse xenograft studies, including tissue trimming, paraffin embedding, microtomy, routine histochemical staining, immunohistochemical (IHC)on validated automated staining platforms, and archival offormalin‑fixed,paraffin‑embedded(FFPE) samples
Work collaboratively within vivoscientists to provide study-aligned histology endpoints as follows:
Characterize new tumor models, including disseminated models of hematologic cancers and patient-derived xenografts (PDXs), and models from drug-resistant patients and conditions
Use IHC-based endpoints with established markers to support pharmacokinetics/pharmacodynamics (PK/PD) and efficacy studiesin mouse models following therapeutic drug testing
Participate in general laboratory maintenance, including buffer preparation, reagent restocking, and basic equipment upkeep
Data documentation and reports:
Digitally archive slides using the Leica Aperioor similarplatform
Accession FFPE samples into a digital specimen database and file blocks in designated storage tomaintainretrievability
Summarizeand present findings to project teamsand capture complete records inanelectronic laboratory notebook (ELN)in a timely manner
Education, Qualifications,Skillsand Experience
Essential Requirements
BS or MS in Biology or related discipline, withat least2 years of experience in a histopathology laboratory
Experience and competency in performing routine histology procedures including trimming, embedding, microtomy, and staining tissues
Strong organizational skills and attention to detail applied tolaboratory responsibilities, data recording,and transparent reporting to project teams
Desirable Skills/Qualifications
Experience developing,optimizing, and validating IHC assays, includingantigen‑retrievaland titeroptimization, and documentation of performance characteristics
Experience using image analysis platforms such as Indica Labs HALO for quantitative analysis of IHC endpoints
Histotechnician(HT) or Histotechnologist (HTL)(ASCP) certification
At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. With one of the broadest and deepest Immunology pipelines in the industry, there are many opportunities to work with new and novel drugs. Our collaborative environment empowers us to take smart risks, challenge the norm, and learn from failures. We are united in our vision to eliminate cancer as a cause of death, making bold moves that truly improve patient outcomes.
Join us in our mission to make a meaningful difference for patients around the world!
The annual base pay for this position ranges from $92,252.00 - $138,378.00. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
Date Posted
28-Apr-2026Closing Date
15-May-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
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