Scientist, In Vivo Pharmacology Immuno-Oncology Early Discovery

We areseekinga highly motivated and independent Scientist in cancer pharmacology witha track recordof scientific excellencein the area ofin vivo cancer modelingto join our team in Waltham, MA USA. As a Scientist in the IO Discovery group, you will be a key member of a team focused on delivering all aspects of in vivo pharmacology support. You will bring your theoretical and practicalexpertisetoestablishand support mouse models, assay systems, and deliver datasets that will have a direct impact on the drug discovery process and pipeline.

Accountabilities:

This is a laboratory-based position within Oncology Research where you willconduct, andanalyze both in vivo experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics. You will be expected to support cross-functional teams and work collaboratively with project leaders to ensure thetimelygeneration and dissemination of critical program data.As a highly organized, self-motivated individual with a strong background in laboratory science, you will stay up to date with relevant technical and intellectual scientificexpertisein tumor biology, pharmacology, and cancer modeling and have a genuine passion for this field of research.

Essential Skills/Experience:

• B.S in relevant scientific area with2-5yearsresearch experience in Cancer biology, Immunology or other related scientific discipline, M.S in relevant scientific area with0-2yearsresearch experience in Cancer biology,Immunologyor other related scientific discipline.

• Experience developing and working withcomplex invivo models, such as xenograft, PBMC and CD34 humanized, patient derived xenograft (PDX) and syngeneic mouse models.

• Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PDand efficacy studies.

• Proficient in technical in vivo injection skills including, but not limitedto:subcutaneous, intravenous, intraperitoneal, and oral gavage.

• Experience with a range ofin vitroskills,e.g.cell culture, molecular biology,immunoblottingand ELISA.

• Works independently, assesses, and reports data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.

• Maintains a well-developed understanding of approaches to drug discovery and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed.

• Ability to design, manage,implementand deliver results for complex multi-functional projects.

• Strong ability to effectively prioritize multiple projects simultaneously whilemaintainingefficient time management.

• Strong interpersonal and collaboration skills together with evidence of delivery in a team-oriented, collaborative environment.

• Excellent communication and presentation skills to report data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.

Desirable Skills/Experience:

• Biotechnology or pharmaceuticalindustry experiencepreferred.

• Experience withoptimizingand performinghigh parameterflow cytometry.

• Experience with xenograft and humanized models of cancer, specifically human Tcellor myeloid engraftment models.

• Experience conducting in vivo research using biologics including peptides, antibodies, antibody-drugconjugatesand small molecules.

• Experience in leading part of a project through key milestones with specific timelines.

At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. Our team is united by a vision toeliminatecancer as a cause of death. We make bold moves that transform the way cancer is treated and truly improve patient outcomes. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs. We foster a mindset of courage where everyone is empowered to innovate and work atpace. Our values are evidence of our dedication to Oncology and our people.

Aboutthe WalthamSite

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse ParkBioHub, just west of the city center. OurBioHubfacility,is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the mostcutting-edgetechnology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employeesbenefitfrom being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the locationprovidesyouthe ability to work in the heart of one of the world’s most vibrant research centers.

Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-servicecafeteriaand copy center. This is whereyou’llfindnewly-designed, activity-basedwork spacesto suit a variety of working styles while increasing collaboration between teams and the greater research community.

As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in2026. Find out more information here:Kendall Square Press Release

Are you ready to join a teamthat'spushing the boundaries of science to change the practice of medicine? Apply now andlet'sstart this journey together!

Ifyou’recurious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Competitiveremunerationand benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus andlong termincentive. We have a generous paid time off program and a comprehensive benefits package.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse teamrepresentingall backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities areprovidedreasonable accommodation toparticipatein the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

The annual base pay for this position ranges from $99,252.00 - $138,378.00. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.