Clinical Pharmacologist/Pharmacometrician

Job Title: Clinical Pharmacologist/Pharmacometrician

Location: Waltham, MA (USA) or Gaithersburg, MD (USA)

As a the Clinical Pharmacologist/Pharmacometricianplaying a hybrid role on our exciting AZ portfolio and primarily responsible for the study related Clinical Pharmacology activities in Oncology drug development and conducts pharmacometrics, population based analyses for the assigned projects. This position requires strong collaboratively approach with other scientists within and external to CPQP as well as cross functionally with other groups within AstraZeneca including medical, biostatistics, regulatory, and translational medicine. The candidate will support the Oncology programs from early pre-IND through first submission using the concepts of MIDD to support drug development and interactions with world health authorities.

Responsibilities:

• Accountable for the conduct of Clinical Pharmacology and model-informed drug development scientific activities and help in input into clinical development plans across diverse modalities.

• Lead pharmacometrics activities in end-to-end drug development using MIDD

• Hands on experience with population based modeling, ER/ES analyses and meta-analyses desireable

• Represent CPQP on clinical development teams and health authority interactions, as needed

• Contribute and Author relevant sections of clinical study protocols, in a matrix environment by working closely with clinical development teams

• Conduct submission related activities and manage contributions of functions, including clinical pharmacology, pharmacometrics, statistical sciences, drug metabolism and pharmacokinetics, biopharmaceutics, and bioanalytical/biomarkers

• Interact with world health authorities (experience preferred) for Oncology projects

• Collaborative authoring experience highly preferred to support writing, review and approval of clinical documents including IB, CSR, PIP, PSP, marketing application sections, health authority briefing documents, and regulatory responses

• External presentations and publications is desireable

• Participation in Departmental initiatives, site activities, and cross-functional teams as need arises

Prior experience: 

• Advanced degree (Ph.D. or PharmD) with 1-3 years of drug development experience preferred.

Special Skills/Abilities:

• Fundamental understanding of the drug development processes from IND through mid to late stages of clinical development desireable

• Prior experience in Clinical Pharmacology, PK-PD modeling and Pharmacometrics in the Oncology therapy area

• Oncology drug development experience desireable

• Team player  and ability to work in a highly matrixed team environment.

• The ability to adapt and influence clinical outcomes using quantitative modeling approaches.

• Ability to deliver effective presentations and excellent written/oral communication highly preferred.

• Thrives in a fast-paced business environment.
  

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we are committed to making a difference by fusing data and technology with scientific innovation. Our curiosity and courage drive us to explore new possibilities in treating complex diseases. We work seamlessly as one team, leveraging diverse global knowledge to create impactful solutions. With opportunities for continuous learning and growth, we push the boundaries of science to deliver life-changing medicines.

Ready to make an impact? Apply now and join us on this exciting journey!

The annual base pay (or hourly rate of compensation) for this position ranges $135,457.60 - 203,186.40 USD Annual.  Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

20-Oct-2025

Closing Date

02-Nov-2025

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.