Cell Therapy Bioanalytical & Biomarker Principal Scientist

Cell Therapy Bioanalytical & Biomarker Principal Scientist
The Integrated BioAnalysis (iBA) group within the Clinical Pharmacology and Quantitative Pharmacology department at AstraZeneca seeks an experienced Associate Principal Scientist or Principal Scientist (level commensurate with experience) to develop bioanalytical and biomarker strategies for new modality therapeutic product programs (e.g. cellular therapies). The ideal candidate will have extensive knowledge and experiences in development of safety and pharmacodynamic biomarkers of various therapeutic products.

Major Duties and Responsibilities

• Devise and implement bioanalytical strategies for new modality programs (e.g. cell therapies) at both pre-clinical and clinical development stages

• Serve as an expert in safety biomarkers for multiple new modality therapeutic programs

• Direct 2-4 scientists (both PhD- and non-PhD levels) in developing, validating and implementing novel bioanalytical assays

• Contribute to engagement efforts with Commercial Research Organizations (CRO) in assay transfer, validation and implementation of bioanalytical & biomarker assays

Educational Requirements and Qualifications

• PhD in relevant field (immunology, biochemistry, biology) and post-doctoral experience in related area

• 4-7 years of experience in bioanalytical/biomarker activities in biopharmaceutical setting

• Experience in identifying &/or developing biomarker assays to monitor safety of therapeutic products

• Extensive experience in PCR, q(RT)PCR and ddPCR assay development and troubleshooting

• Experience with flow cytometry is preferred

• Knowledge of Good Laboratory Practice (GLP) regulations

• Understanding of drug development process

• Scientific management experience is preferred

Skills and Abilities

• Ability to manage multiple complex programs and delivery timelines concurrently

• Ability to work independently in a highly-matrixed organization to deliver on goals

• Excellent verbal and written communication skills
  

The role is based in South San Francisco, California.  

South San Francisco, CA Campus

South San Francisco is a single world-class facility in the Cove at Oyster Point, in the heart of the area’s vibrant biotechnology and technology community. It’s our newest site that’s been designed to enable side-by-side talent to make the impossible, possible at the center of the biotechnology and high-tech industry.

Campus amenities

Thoughtfully designed, the amenities center and outdoor spaces at the SSF campus, enhance each person's daily experience and create an active environment.​ Custom-designed to encourage collaboration and spark scientific innovation, the SSF site's facilities are equipped with cutting-edge open lab space and an office environment that incorporates AstraZeneca's iWork philosophy, an activity-based working approach that embraces industry best practices.

Additional highlights of the SSF site include:

• Building and lab space that reflects AstraZeneca's commitment to minimizing the environmental footprint of oru products and processes
• Cutting-edge open and agile lab design, including windows into labs from public spaces to see science in action
• Focus on health and safety for employees, with on-site pantries offering organic foods, adjustable desks and ergo dynamic chairs, treadmill-equipped team rooms, and an on-campus gym
• Collaboration is at the core of our culture and a key driver of innovation.
• The SSF site brings together the best of both worlds - a shared drive across our employee base to advance great science and bring new treatments to patients, while providing an opportunity to tap into the Bay Area's transformative biotech ecosystem, helping to foster great progress internally and externally.

Benefits:

AstraZeneca is a leading company in the healthcare industry, with a mission to enrich the lives of others. It’s our business to support healthy living, not only for our patients, but also for our employees. Our benefits program is flexible enough to meet employees’ varying needs, and offers valuable choices.

Are you already imagining yourself joining our team? Apply today!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential.

Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next?

Are you already imagining yourself joining our team?

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.