Scientist, Clinical Pharmacology & Safety Sciences

In AstraZeneca's Cell Therapy division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. We have the potential to grow our pipeline and positively impact the lives of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. This role is part of the Oncology R&D team tasked with supporting Clinical and Commercial production across multiple sites.

AstraZeneca is on the lookout for a motivated Scientist with knowledge in next-generation sequencing (NGS), molecular biology, and assay development. You will build NGS-based assays, prepare sequencing libraries, organize and analyze results, and share insights during team meetings. This position is located in Santa Monica, CA, and reports to a Senior Scientist.

You Will:

• Prepare tissues and primary cells for single-cell suspension

• Build bulk and single-cell NGS workflows, including 10X immunoprofiling

• Perform Illumina sequencing of libraries

• Troubleshoot to enhance assay performance

• Design and conduct assays for NGS projects both independently and collaboratively

• Contribute to data management and tracking using ELN

• Meet deadlines while maintaining accurate records and communicating results

• Share findings in internal and cross-functional meetings

• Help with additional tasks to achieve corporate goals

You Have:

• Five (5) years with BS/BA, or two (2) years with MS/MA in immunology, cellular or molecular biology or in a relevant discipline with related lab or industry experience.

• Background in genomics and molecular biology

• Hands-on experience with NGS library preparation

• Proficiency with single-cell NGS platforms (10X Genomics)

• Experience with using Illumina sequencers (NovaSeq X)

• Experience with tissue dissociation and preparation of primary cells for single-cell suspension

• Well-versed in cell culture aseptic techniques

• Organizational and record-keeping abilities

• Team-oriented attitude with the capability to work independently and in collaboration

• Open to taking on temporary responsibilities beyond the initial job description

The annual base salary for this position ranges from $80,653 to $120,980. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles).

Our Benefits:

Benefits offered include:

• A qualified retirement program [401(k) plan]

• Paid vacation, holidays, and paid leaves

• Health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment.

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We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender, gender identity or expression, or veteran status. We are proud to be an equal opportunity workplace.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.