Scientist, Analytical Sciences

Scientist, Analytical Sciences

Introduction to role

We are looking for an experienced Scientist to join Analytical Operations within Analytical Sciences, Cell Therapy Development and Operations. This position is focused on the development and optimization of the genomic assay testing function to support process and product characterization of engineered cell therapy.

The Scientist will work with Analytical Development, Process Development, and Quality Control to deliver quality data by maintaining continuous operations of genomic assay testing functions. You will have expertise in genomic assays, particularly those relevant to DNA extraction, digital PCR, qPCR, and RNP activity. This role is on-site in Santa Monica, CA and reports to a Senior Scientist within Analytical Sciences.

Accountabilities

• Lead the development of operational processes & continuous improvement of the genomic function within Analytical Operations.  

• Manage critical reagent inventory, assay control material, and general consumables to maintain team’s capabilities to execute genomic assays.  

• Perform genomic assays including, but not limited to, DNA/RNA extraction, digital PCR, qPCR, and RNP activity assays. 

• Maintain sample identity from sample source to molecular derivatives and its associated results.  

• Coordinate to produce assay control materials with Process Engineers or External Suppliers and characterize material in a timely manner to support routine testing.  

• Lead in the method transfer of genomic assays into the Analytical Operations team by assessing incoming test methods, critical reagents, and training schedule. 

• Collaborate with method & automation developers to optimize methods for high throughput testing and streamline documentation & analysis. 

• Maintain records of executed methods and reported results for samples and assay control material. 

• Monitor assay trending and collaborate with method developers to troubleshoot analytical assays. 

• Expand laboratory and operational skills to support department needs 

• Provide technical mentorship ensuring scientific rigor and operational excellence in the lab. 

• Maintain laboratory instruments, ensuring calibration, maintenance, and troubleshooting are performed. 

Essential Skills/Experience

• Three (3) years with BS/BA, or two (2) years with MS/MA in immunology, Cell Biology, Oncology, Molecular Biology, or a related discipline with experience in a biotechnology, biopharmaceutical, or academic setting. 

• Strong expertise in genomic assays, especially those pertaining to human sample derivatives, digital PCR, and qPCR.  

• Hands-on experience with media preparations and suspension/adherent culture work: thaw, culture, expand, and cryopreserve 

• Proficiency in immune cell culture, including primary T cells or engineered immune cells. 

• Proficiency in data analysis and troubleshooting of genomic analytical assays 

• Proficient knowledge of general cell therapy processes and understanding of sampling and testing points for characterization to support process development 

• Experience in flow cytometry, immunoassay, or cell-based assays is a plus 

• Ability to clearly convey scientific findings and development rationale. 

Desirable Skills/Experience

• Working knowledge of protein purification technologies and common analytical methods (e.g., SEC-UPLC, LC-MS, SDS-PAGE, CE).

• Familiarity with lab automation scheduling software; Green Button Go preferred.

• Basic scripting for data handling (e.g., Python, Jupyter) is a plus, not required.

• Exposure to imaging or flow cytometry platforms and analysis tools (iQue, Attune, FlowJo) is beneficial for specific assays but not central to the role.

AstraZeneca offers an inspiring environment where you can apply your expertise in new ways. We thrive on change and embrace the unknowns, taking calculated risks to deliver new medicines to patients. Our collaborative approach encourages learning from diverse minds, pushing boundaries to find innovative solutions. Here, every challenge is an opportunity for growth, supported by leaders who empower you to make a tangible difference in society.

Why AstraZeneca?

At AstraZeneca, we push the boundaries of science to deliver life-changing medicines. You'll be part of a globally connected team working at the forefront of innovation—driving advances that impact patients around the world. With a strong emphasis on collaboration, continuous improvement, and scientific excellence, this is your opportunity to lead a team that makes a real difference.

Diversity and Inclusion at AstraZeneca

We believe that diversity drives innovation. AstraZeneca is committed to building an inclusive culture that celebrates diverse perspectives and fosters belonging. We welcome all qualified applicants and ensure compliance with applicable laws regarding inclusivity and employment eligibility. Individuals with disabilities can request reasonable accommodations throughout the recruitment process.

Ready to make an impact? Apply now and join us in our mission to transform patient lives through scientific innovation!

The annual base salary for this position ranges from $87,200 to 130,800. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). 

Date Posted

09-Feb-2026

Closing Date

22-Feb-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.