Senior Scientist – Particle Engineering (12 Months FTC)

Senior Scientist – Particle Engineering (12 Months FTC)
Macclesfield UK (On-site)

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death.

Come and join our AZ team where you will play a pivotal role in this exciting period of development!!

Join our Particle and Process Engineering Team in ECD based in Macclesfield UK as a Scientist or Senior Scientist. We are looking for an enthusiastic, motivated and highly capable individual who can work closely with cross functional teams including chemists and many other scientists within the drug product units to contribute to Pharmaceutical Science projects. You will be involved in designing and implementing new final active pharmaceutical ingredient (API) processes with a focus on delivery quality API physical attributes, form and particle to meet clinical timelines and demands.

You may also have the opportunity to plan and drive improvement projects, use new technologies or modify our ways of working within AstraZeneca or externally with our Contract Development and Manufacturing Organisations (CDMOs).

Key Responsibilities:

• Provide crystallisation expertise in process development, process scale-up and manufacturability for drug substance and intermediates as an integral part of route development.

• Drive the Drug Substance control strategy, ensuring processes are fully understood and will robustly deliver consistent drug substance quality and align with Drug Product control strategy.

• Work collaboratively with colleagues in Drug Product Development to identify and define the required solid form and particle properties for downstream processing.

• Contribute to complex projects focusing on sustainable process development and manufacture of drug substances and provide the link through to Drug Product.

• Act as a scientific expert to deliver our science and technology strategy and other improvement activities both internal and external to the ECD department.

• Develop an external network (industrial and academic) to bring learning and innovative crystallisation and particle engineering science into AstraZeneca.

• Tackle and provide technical leadership for complex scientific problems.

Requirements:

• A degree and / or PhD in Chemistry or Chemical Engineering.

• The ability to support multiple projects as a lead crystallisation scientist.

• Experience and motivation for Laboratory work.

• Enthusiasm for crystallisation process development in the laboratory

• Provide support for the development and delivery of final API processes internally & externally in priority and if time on intermediates.

• Have the ability to work collaboratively with colleagues in Drug Product Development in multi- functional teams to define desired solid form and particle properties for formulations, manufacturability and bioavailability.

• Awareness in a range of particle/materials characterisation techniques.

• Proficiency with inline Process Analytical Technology (PAT).

• Generating, reporting and interpreting high quality data with clear impact to development projects.

• Have the ability to independently represent the department and the Particle and Process Engineering skill sets within multi-functional teams.

• Ability to present information and engage in discussions in multi-disciplinary project teams.

• Effective communication and influencing skills.

• Continuously develop yourself and your colleagues via training and shared learning experiences to improve our efficiency and effectiveness.

• Ensuring own work is performed and recorded in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Manufacturing Practice (GMP).

Desirables:

• Experience of working in the Pharmaceutical or Fine Chemicals Industry.

• Involvement with working with Contract Development and Manufacturing Organisations (CDMOs).

• Involvement in the development and manufacturing of non-crystalline or large molecule entities.

• Knowledge of particle size reduction unit operations.

• Experience in technology transfer and commercial production.

• Experience of leading and driving improvement projects or new ways of working.

• Collaboration with external partners investigating a new technology or process and implementing these within an industrial setting.

In Office Requirement:

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of five days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?

At AstraZeneca's Oncology R&D business area, you'll be part of a team playing a critical role in driving meaningful change in the way we predict, prevent and treat patients' conditions. We're actively embracing and investing in technology, harnessing digital, data and analytics to reimagine the future of healthcare and deliver improved outcomes to patients beyond core medical. We're shaping the future, improving and speeding up portfolio development, improving the patient experience and outcomes at clinical trials. Join the team that is co-creating a digital ecosystem with patients at its core.

Competitive salary and benefits package on offer.

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, colour, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.