Senior Scientist, Protein Engineering and Novel Modalities, Biologics Engineering, Oncology R&D

Senior Scientist, Protein Engineering and Novel Modalities, Biologics Engineering, Oncology R&D

Are you ready to push the boundaries of science and make a real impact in the field of oncology? We are on the lookout for a highly motivated Senior Scientist to join our dynamic team in Biologics Engineering. This role is perfect for someone who thrives at the intersection of innovative technology and biology. Our team is dedicated to discovering, designing, engineering, and optimizing next-generation biologics to develop groundbreaking drug candidates across key therapeutic areas. As part of the Protein Engineering & Novel Modalities team, you'll be at the forefront of designing and optimizing bi/multi-specific antibody therapeutics, collaborating with experts across the AZ Research organization. Join us in our mission to deliver life-changing medicines and address unmet medical needs.

Accountabilities

• Lead collaborative workstreams with a diverse group of scientists across all therapeutic areas to ensure timely progress in research projects and drive technological innovations.
• Conceive, design, and execute the engineering of innovative multispecific antibodies with improved selectivity and developability.
• Conduct biochemical, biophysical, and functional characterization of antibodies and multispecific modalities.
• Prepare, analyze, and present data internally and externally.

Essential Skills/Experience

• PhD and 2-5 years of experience in Chemical or Biological Engineering, Biotechnology, Molecular Biology, Biochemistry or other relevant scientific field with experience in protein engineering and/or bispecific antibody technologies.
• Extensive hands-on experience in molecular biology and antibody/protein engineering, including; design, expression, purification and biochemical/biophysical characterization of various bispecific antibody formats.
• Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines.
• Deep understanding of various imaging/multicolor flow cytometry-based instruments and data analysis programs.
• Comprehensive experience in tissue culture techniques and functional cell-based assay development.
• Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset.
• Track record of scientific innovation as evidenced by scientific publications, patents and oral presentations at conferences.

Desirable Skills/Experience

• Understanding of protein and antibody structure-function relationships.
• Experience in engineering antibodies with improved properties (e.g., affinity, solubility, and other attributes related to developability).
• Experience with bispecific therapeutics, e.g., T-cell engagers, ADCs, checkpoint inhibitors.
• Background in antibody discovery using one of several display-based technologies.
• Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management.

At AstraZeneca, we are driven by a shared vision to transform the lives of patients living with cancer. Our team is united by a pioneering spirit that embraces bold moves and innovative approaches to improve patient outcomes. With one of the broadest Oncology pipelines in the industry, we offer countless opportunities to work with novel drugs and cutting-edge technologies. Our collaborative environment fosters growth through diverse perspectives and interdisciplinary learning. Join us as we lead the way in changing the practice of medicine.

Ready to make a difference? Apply now to join our team!

The annual base pay for this position ranges from $108,473.60 - 162,710.40. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. 

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.