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Scientist - B-Cell Technologies

Lieu Gaithersburg, Maryland, États-Unis Job ID R-132664 Date de publication 07/03/2022

Scientist – Scientist- B-Cell Technologies

Location: Gaithersburg, MD

Do you have expertise in, and passion for therapeutic antibody discovery using innovative B-cell technologies? Would you like to apply your expertise to impact the next generation bio-therapeutics portfolio in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

What is Happening at AstraZeneca

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe. We turn ideas into life changing medicines. Working here means being ambitious, thinking big and working together to make the impossible a reality.

About Our Gaithersburg Oncology Hub

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we host some of the most pioneering technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria, copy center, game rooms, community garden, and much more. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while growing collaboration between teams.

The Team

The Biologics Engineering (BE) department at AstraZeneca is constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re applying our expertise in antibody discovery and protein engineering to enable novel therapeutic approaches to Oncology, Respiratory, Inflammatory, Cardiovascular and Infectious diseases. The group is seeking a dedicated and highly motivated senior scientist with strong background in single B-cell technologies, molecular and cell biology. We offer a unique and strong collaborative network as part of the AstraZeneca family, and together we explore paradigm shifting exciting new technologies.

This Opportunity

We are seeking a highly motivated scientist to help design, optimize and implement novel immunization strategies to increase the repertoire diversity, specificity and potency of antibodies using transgenic mice. The role entails developing immunization strategies against complex membrane targets, isolation and characterization of hybridoma/B-cells, assay development, molecular cloning of V-genes and conducting selections for high-affinity antibodies binding to specific targets. The successful candidate will add to our team of multidisciplinary and passionate scientists excited by research at the interface between technology and Biology. They will be a well-organized and a highly productive bench scientist who can design and complete experiments efficiently, as well as analyse, interpret and present data.

Education & Experience Requirements:

A Master’s degree with 2-4 years of experience or Bachelor’s degree with 4-6 years of equivalent experience in in-vivo work, hybridoma generation, B-cell technologies, cell biology, and assay development

Required Skills:

  • Experience working with immunizing mice, hybridoma generation or using single B-cell technology for antibody generation
  • Ability to execute experiments, develop assays, optimize protocols, and interpret experimental results
  • Strong communication skills in a team environment, ability to learn and embrace new technologies quickly and science driven innovation

Desired Skills:

  • Hands on experience with in vivo methods and hybridoma technology
  • Comfortable with using automation for high-throughput isolation of antibodies/antibody genes
  • Experience with next-generation sequencing, High through put flow-cytometry/FACS, ideally for single and bulk antigen specific B-cell sorting & population analysis
  • Basic biochemical screening assay skills e.g. ELISA, cell based binding assays (e.g. iQue3)
  • Experience in cell line engineering

Why AstraZeneca

At AstraZeneca, any opportunity can be the start of something big. Delivering life-changing medicines is about being entrepreneurial, finding those moments, and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, ground-breaking innovative methods, and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next!

Are you already envisioning yourself joining our team? Good, because we can’t wait to hear from you!

If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We align with all applicable laws and regulations on inclusivity in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

AstraZeneca has taken critical steps to protecting colleagues, loved ones, and patients from COVID-19 and its variants. Accordingly, AstraZeneca requires all US employees to be fully vaccinated for COVID-19 prior to the first date of employment. AstraZeneca will consider requests for reasonable accommodations as required by applicable law.



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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