Scientist, Cell Therapy Process Development

Scientist, Cell Therapy Process Development

This position will involve performing experiments to design, optimize, characterize, and scale up consistent CAR-T cell processes. In this role, you will execute cell therapy experiments and projects through cross-functional interactions with Research, Analytical Development, and other functions. Join us in pushing the boundaries of science to transform the lives of patients living with cancer!

Accountabilities

• Designs and performs laboratory experiments with guidance from senior team members to develop and optimize CAR-T cell processes.
• Makes detailed observations, analyses data, and interprets results. Demonstrates scientific rigor in assessing own data and that of others. Utilizes forward-looking perspective to contribute to decision making.
• Familiar with different analytical methods that are used to characterize T cell proliferation and phenotype.
• Authors and contributes to development reports, scientific publications, patents, and regulatory submissions.
• Effectively presents results at internal meetings and external scientific meetings.
• Works effectively and collegially as a team member within a highly matrixed organizational structure.

Essential Skills/Experience

• Bachelors degree with 4+ years of relevant work experience or Masters degree with 2+ years of relevant work experience
• Strong background in mammalian cell culture
• Experience with use and troubleshooting of cell processing using common platforms
• Excellent partnership and communication skills including proven technical writing skills, good publication records
• Strong background in experimental design and data analysis skills
• Ability to learn and adopt new technologies quickly, work independently, multi-task, and manage shifting priorities

Desirable Skills/Experience

• Bachelors or Masters degree in Chemical/Biochemical/Biomedical Engineering, Biotechnology, Biochemistry, Biological Sciences, or related field
• Cell production and cell scale-up technology experience
• Analysis of cell characteristics and phenotype using flow cytometry-based instruments and data analysis programs
• Experience running experiments using DOE principle
• Understanding of biology and bioprocessing supporting adoptive cellular immunotherapy as a therapeutic modality desired
• Uses knowledge of immunology, cellular engineering, T cell biology, T cell therapy, and bioprocess engineering and exhibits extensive experience working with multiple gene delivery systems for immune cells
• Skills applicable to scale up and scale down of CAR-T processes and advanced analysis of flow cytometry data

At AstraZeneca, we are at the forefront of applying science to studies and using innovative approaches to create new possibilities. Our interdisciplinary approach includes novel biomarkers, AI, novel endpoints, and cutting-edge trial designs. By constantly innovating, we develop life-changing medicines that transform the way cancer is treated and improve outcomes for patients everywhere. We are united in our vision to eliminate cancer as a cause of death.

Ready to make a difference? Apply now!

The annual base pay for this position ranges from $80,653.60 - 120,980.40. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. 

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.