Safety Pharmacologist, Associate Director

Safety Pharmacologist, Associate Director

Introduction to Role:

Join our Safety Pharmacology team at AstraZeneca as an Associate Director, Safety and Mechanistic Pharmacology. We are currently seeking an emerging Safety Pharmacologist to help deliver our growing portfolio. Our team plays a central role in progressing a rich and diverse pipeline across all of our therapeutic areas. We work collaboratively to deliver safety science from early discovery through clinical development, with emphasis on the science and studies required to enable the clinical development of new medicines.

Accountabilities:

In this role, you will apply your extensive drug discovery expertise to support the progression of a broad portfolio of drug projects. You’ll be responsible for authoring Safety Pharmacology sections of submission documents, engaging with and responding to Health Authority questions and contributing to the labelling of new products. You will also design and interpret safety pharmacology studies enabling first time in human submissions as well as investigative work at all stages. This will involve close collaboration with a wide range of experts in a highly matrixed environment across the development chain, for multiple project safety teams in parallel.

Essential Skills/Experience:

• Extensive experience in pharmaceutical development, with a PhD (or equivalent experience) in pharmacology, toxicology, pathology or a related Natural Science field.

• At least 5 years’ experience working in an industry role with direct experience of Safety Pharmacology, with exposure to non-clinical safety assessment in projects both in discovery and development.

• Demonstrable expertise in the design and interpretation of in vitro and in vivo studies, translating scientific findings into applicable information in a drug development environment.

• Understanding of the external factors that shape the scientific and regulatory landscapes relevant to Safety Pharmacology.

• Ability to interpret complex datasets and communicate clear conclusions to diverse audiences, enabling decision-making within project teams

• Strong prioritisation skills and ability to work in a highly matrixed environment.

• Proven scientific track record and problem-solving capabilities.

Desirable Skills/Experience:

• Track record of authoring nonclinical regulatory submissions (including Secondary and Safety Pharmacology sections) and involvement in health authority interactions.

• Familiarity with pharmacokinetic-pharmacodynamic and systems pharmacology approaches.

• In depth knowledge of cardiac function, ECG and imaging modalities.

• Diplomat of Safety Pharmacology, DABT or ERT accreditation.
  

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world!

At AstraZeneca, we are driven by our desire to understand and reveal new insights. We are free from fear of failure, free to ask the right questions, make bold decisions, and dig deep into the biology of complex disease. We are always listening and learning from people who live with the diseases our medicines treat. It enables us to better understand their needs and, ultimately, diagnose and design the right treatments to impact patients' lives. We are harnessing digital, data science & AI to help us achieve the next wave of breakthroughs.