Global Product Lead, Oncology R&D
Global Product Lead, Oncology R&D
Location: Gaithersburg, MD USA
At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.
We are committed to advancing the science of oncology to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. We currently have nearly 100 Phase 1, 2, 3 and Lifecycle Management Oncology projects in our robust pipeline. We deliver the Research & Development for Oncology through our newly created Oncology R&D Unit. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs.
The Sr. Director/Global Product Lead (GPL) will have overall leadership and accountability of multiple global cross functional early global product teams across diverse biological mechanisms from candidate selection through Phase III investment decision across 3 of the major platforms (IO, ADC, Cell Therapy). This individual will be accountable for the strategic leadership and execution for the product candidates (essentially the ‘CEO’ of the asset). The successful candidate will have oncology clinical drug development experience, demonstrated leadership, and be able to critically evaluate the science, clinical data and competitive landscape that underlies these programs. The
candidate should be able to effectively communicate across a broad range of audiences and have an ability to clearly
articulate project specific strategies as it relates to the overall oncology strategy.
Major Duties and Responsibilities:
Leads global product teams from preclinical candidate selection through proof of concept leading to Phase III
Investment decisions. If appropriate, GPLs may have the opportunity to continue to lead assets through late development/ registration.
Single point of accountability for the strategy, budget, timeline and execution of a portfolio of pre-clinical and clinical stage therapeutic candidates.
Create integrated product development plans which are aligned with business objectives and are differentiated from competitor products.
Leads and communicates the project development strategy at governance meetings to secure funding and endorsement of the strategy.
Leads the global project team to effectively manage/mitigate/communicate risk. Responsible for monitoring emerging data and pivot when deemed necessary.
Responsible for maintaining a high degree of team effectiveness through collaboration, influence, and, as necessary, coaching and mentoring of cross-functional team members.
Maintains relationships with external investigators to ensure projects are consistent with evolving clinical
Graduate degree such as a PhD or an MD/PhD is required
Demonstrated success developing IO agents.
Industry experience in drug development including experience in early phase non-clinical and/or clinical drug development and regulatory knowledge.
Strong knowledge and understanding of the Oncology therapeutic area with experience in diverse biological
Broad understanding of the evolving clinical landscape in oncology.
Demonstrated experience leading and motivating teams in a highly matrixed environment.
Proven record of cultivating and managing internal and external cross-functional collaborations.
Demonstrated success in influencing colleagues and senior leaders in various departments.
Must demonstrate high integrity.
Experience in the development of biologics is highly desirable.
ADC and/or IO (T cell engagers, oncolytic viruses, immune redirecting agents, etc) development experience is highly desirable.
Due diligence experience as GPLs often are required to participate in companywide initiatives.
Next Steps – Apply today!
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.