Director, Translational Medicine Lead, Hematology

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery,developmentand commercialization of prescription medicines for some of the world’s most serious diseases. We are more than one of the world’s leading pharmaceutical companies.AstraZeneca has a multifaceted environment that cultivates collaboration and innovation. We attract top minds, and we nurture and build talent.

Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices3 days a week. Our headispurposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects.

Our dedication to sustainability is also central to our culture and part of what makes AstraZenecaa great placeto work. We know the health of people, the planet and our business are interconnected which is whywe’retaking ambitious action to tackle some of the biggest challenges of our time, from climate change to access to healthcare and disease prevention.

Introduction to Role:

Within Hematology R&D, we are committed to advancing science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs.

The Hematology Research and Development (R&D) team is accountable for all drug development activities in hematology research from first-in-man studies, all the way to late-stage trials leading to drug approval by regulatory agencies (Phase 1, 2, and 3 trials). The team strives to deliver compelling preclinical, clinical, and translational data packages providing confidence in the dosing strategy, tolerability profile, and therapeutic efficacy of our candidate drugs to support investment in late-stage clinical development, leading to drug approval.

We are seeking aDirector, Translational Medicine Lead inHaematologyR&Dto join a world classHaematologyR&D unit.  In this role you will be accountable fordeliveryof robust,scientifically-drivenbiomarkers in drug discovery and development programs for hematology programs. You will have the opportunity toimpactan industry-leading portfolio of hematology programs frominceptionthrough to life cycle management for marketed drugs. 

Accountabilities:

• In partnership with the Translational Medicine team, lead the implementation of strategic vision that enables target identification,indicationselection, earlyindicationof biologicalactivityand patient stratification/selectioninHaematology.

• Deliver biomarkers for clinical studies based on the best available science and technologies.

• Generate biomarker data to guideindicationselection and identification of targeted patient populations.

• Measure target engagement reliably and quantifiably to inform clinical decisions for selectingtherapeuticallyrelevant doses and schedules.

• Understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.

• Define novel mechanisms of resistance targeted therapies by studying tumors at relapse.

• Collaborate with broader Oncology Research and product development teams tofacilitateappropriate incorporationof Translational Medicine strategies for molecules in early phases of development in Oncology.

• Collaborate with clinical development and operations teams to implement translational strategy, sample collections, and analyses in clinical studies related toHaematology.

• Collaborating with the clinical development team to design and executeappropriate phase1/2a study(s) to generate FIH safety, PK, PD, PK/PD,biomarkeror efficacy/PoC data to support continued clinical development or no-go for program

• Manage internal and external research collaborations in areas of clinical technologies and oncology translational research.

• Ensure complex clinical assays developed andvalidatedinternally or externally are fit for purpose.

• Contribute to and ensure the quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications and recommendations to development teams and management.

Minimum Qualifications:

• PhD and /or MD with experience in oncology drug developmentrequired.

• Oncology training isrequired, preferably board certified or board eligible in Oncology and/or Hematology

• 5+ years of experience in drug development in pharmaceutical or biotech industries

• In-depth knowledge ofHaematologydisease area biology and translational science, ideally withexpertisein myeloma,leukemiaand lymphoma.

• Experience with T cell engagers, antibody-drug conjugates, or cell therapy modalities is preferred

• Proven communication,presentationand influencing skills.

• Highly developed problem solving and risk management skills.

• Ability to drive, manage,executeand deliver results for complex multi-functional projects.

• Highly developed collaborative working skills.

• Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca.

• Proven ability to motivate and develop others.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being ambitious - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, groundbreaking methods, and bringing unexpected teams together. Interested? Come and join our journey. 

So, what’s next?

Are you ready to bring new insights and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours. 

The annual base pay for this position ranges from$175,498.40 - $263,247.60 USD. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity; eligibility toparticipatein our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coveragein accordance withthe terms and conditions of the applicable plans.Additionaldetails of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.