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Lieu: Gaithersburg, Maryland, États-Unis
ID de l'offre 12194199
Date de publication: 06/12/2019

If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  Here at MedImmune, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Key Responsibilities:

Responsible for planning and executing the purification and conjugation of protein critical reagents to advance the MedImmune pipeline.  Perform purification and conjugation process development for complex biopharmaceutical drugs such as bi-specific antibodies, fusion proteins, and proteins expressed in E.coli that require re-folding. Candidate is expected to participate in solving challenging protein purification problems such as aggregate removal, endotoxin removal, conjugation, self association, and glycoform separation. Provides technical expertise in pipeline reagent preparation and process scale-up. Coordinates closely with the research department, cell culture group, and analytical biotechnology group in order to meet project timelines and company goals. Additional job expectations include analyzing and interpreting analytical and process data, understanding process operations and contributing to appropriate experimental plans. The candidate should maintain accurate records of data and actively participate in laboratory organization. The individual should professionally deliver experimental plans and results, possess excellent writing and communication skills, and show attention to detail to support the preparation and review of development reports and presentations. Job complexity: The job is fairly complex, requiring an understanding of the biological and chemical properties of recombinant proteins, process design, and data analyses.

Supervision: A high level of independence is required for this position.


B.S./B.A. or M.S./M.A in biochemistry, chemical/biochemical engineering, or related field

Associate Scientist I: BS with 5+ years of related experience,MS with 2+ years of related experience

Associate Scientist II: BS with 8+ years of related experience,MS with 5+ years of related experience

Preferred Qualifications:

Practical experience in biotherapeutic reagent preparation and purification process development

Experience developing chromatographic purification processes for monoclonal antibodies,  bispecific antibodies, fusion proteins, and conjugated proteins

Experience solving challenging protein purification problems such as aggregate removal, endotoxin removal, conjugation, self association, and glycoform separation

Expertise in protein chromatography and tangential flow filtration

Expertise with the AKTA platform and Unicorn software

Experience performing analytical testing such as HPSEC, SDS-PAGE, and BioAnalyzer

GLP/GMP experience desirable

Familiarity with tech transfer to pilot and commercial manufacturing

This role requires the ability to troubleshoot and collaboratively resolve complex problems under tight time constraints.

This role will require good oral and written communication skills. Must be a team player and customer focused.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by lawAstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

Associate Scientist I / II

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