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Clinical/Senior Clinical Pharmacometrician

Lieu Cambridge, Angleterre, Royaume-Uni Job ID R-065009 Date de publication 11/04/2019

At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible into reality. We're focused on the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can change the course of medicine and bring new ideas to life.

As a Clinical/Senior Clinical  Pharmacometrician, you will be responsible for population PK, PKPD, exposure-response, disease modelling, and simulations in all clinical development phases in oncology, with special emphasis on biologics . You will have the opportunity to contribute to state-of-the-art modelling and simulation (M&S) approaches. The desired candidate will have strong quantitative skills to influence designs and conduct decision-making at the project level.

Main duties and responsibilities:

  • Accountable for expert data integration, analysis, interpretation, and reporting of M&S results within the project level
  • Accountable for executing state-of-the-art M&S techniques with value for the project
  • Use of M&S to influence study designs and decisions
  • Scientific and strategic input into clinical, and post-approval development plans
  • Support Biologic License Application in clinical pharmacology dossiers
  • Development of mechanistic or empirical PKPD/tumor growth inhibition/time-to-event models to support projects for late-stage oncology assets
  • Presentation of M&S results in internal and external forum
  • Contribution to internal initiatives to develop the pharmacometric discipline
  • Participation in and accountability for peer review of ongoing activities, reports and presentations
  • Compliance with Good Clinical Practice (GCP) regulations as well as internal/external guidances
  • Good knowledge of clinical pharmacology pathways involved in oncology, including the potential role of pharmacodynamic biomarkers to inform M&S approaches

Essential Requirements:

  • PhD degree preferred or equivalent (M.Sc./Pharm.D.)
  • 3 years of drug development experience, with emphasis on pharmacometrics
  • Expert knowledge of pharmacokinetics and Model-Based Drug Development
  • Excellent skillset in written and verbal communication
  • Demonstrated ability to identify, develop and execute M&S activities
  • Knowledge of regulatory, compliance, processes, standards and issues in pharmacometrics
  • Oncology disease domain knowledge
  • Familiar with PK and statistical softwares such as NONMEM, R, Matlab, Winbugs, SAS, Monolix

Desirable Requirements:

  • International reputation gained from publishing in pharmacometrics



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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