Global Clinical Head, Immunology Cell Therapy

Job Profile: Global Clinical Head, Immunology Cell Therapy

Location: Office-based role in Boston Seaport MA

Are you a visionary leader in clinical drug development, possessing the capabilities to drive a successful strategy in accelerating the development of cellular therapies for patients with immune-mediated diseases? Are you dedicated to revolutionizing the treatment of immune-mediated diseases and significantly impacting patients' lives? Do you have a strong passion for science and meaningful clinical development experience in Immunology and CAR-T cell therapies? Do you possess both strategic and operational leadership skills? If so, we invite you to join us! We are seeking a Global Clinical Head, Immunology Cell Therapy based in Boston Seaport.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. We are more than one of the world’s leading pharmaceutical companies.

Immunology Cell Therapy

Our ambition is to build a world-class organization that accelerates the delivery of ground-breaking cell therapies for patients with immune-mediated diseases. It’s our big vision that unites and inspires us. Cell therapies represent a fundamental evolution of how drugs are discovered, developed and manufactured, these new advanced potentially curative cellular modalities require a new development strategy to ensure their rapid availability to patients. With multiple autoimmune and inflammatory indications and clinical-stage cell therapies in global development, we keep pushing forward, focusing on ground breaking science with the latest technology to achieve breakthroughs.   AZ is a place built on courage, curiosity and teamwork – we make bold decisions driven by patient outcomes.

What You’ll Do

The Global Clinical Head for Immunology Cell Therapy holds a senior leadership position within a new and dynamic organization at AstraZeneca. This is an exceptionally exciting and prestigious role, contributing significantly to AstraZeneca's global objectives and the value targets of our portfolio. Reporting directly to the Head of Immunology Cell Therapy in Boston, this individual will also be a pivotal member of the leadership team. As the Global clinical head, they are responsible for spearheading the program and related studies in immune-mediated diseases. The GCH is the most senior medical scientific expert on an asset/product/indication team and is a core member of the Franchise Team (if applicable) and/or the Global Product Teams (GPT). Moreover, this role offers the outstanding opportunity to collaborate closely with cross-functional teams at the enterprise level, including Oncology, Alexion, and several development partners, thereby improving the overall impact and reach of the position.

Responsibilities:

• Provide expert clinical and medical expertise input into overall cell therapy programs and portfolio strategies.
• Accountable for all clinical scientific aspects of the product/asset, including the benefit/risk of a product and/or asset as well as the scientific strategies for clinical components of the Target Product Profile (TPP), Target Product Claim (TPC), Clinical Development Plan (CDP), Clinical components of regulatory documents and core labelling texts.
• Single point accountable leader for the design, delivery and interpretation of clinical studies ensuring

the ethical and scientific integrity of the plans, studies and the products in compliance with GCP

• Provide impactful medical strategy and cell therapy expertise to Research, Translational Medicine, Early and Late-stage Clinical Development and Commercial Partners, including in the development of therapeutic area strategy
• Closely follow medical developments within assigned areas, including cell therapy for autoimmune/inflammatory diseases, and disseminate new information within Clinical Development and wider organization, to transform trends and emerging data into agile clinical plans
• Work closely and collaborate across early and late clinical development, partner functions and wider AZ organization in Oncology and rare disease to ensure the design and delivery of clinical development plans with high quality and speed

Essential Qualifications Required for this Role

• M.B.B.S. or M.D. degree, MD/PhD with speciality or experience in the Immunology therapeutic area and CAR-T cell therapies
• Postgraduate subspecialty training medical training in a relevant field with a history of holding substantive clinical positions at the attending/consultant level preferably at a major academic medical center
• Minimum of 10+ years of expertise & experience in both the clinical setting and the drug development process, specifically in designing development strategies and delivering Phase 1-3 programs coupled with the appropriate regulatory and commercial insights required to achieve a successful product approval and launch.
• Expertise & experience in all stages of the drug development process coupled with the appropriate regulatory and commercial insights.
• Adaptive problem-solving and learning and the ability to navigate complex organizations and systems
• Ability to influence both high-level internal and external stakeholders. 
• Ability to frame clear & succinct messages and simplify the complexity of decision-making
• Track record of leading successful high-performing global cross-functional teams as well as line management experience.
• Fully conversant with science as it relates to the brand
• Strong leader seen as credible with Key Opinion Leaders, Payers and Scientific communities. Specific and relevant Therapy Area expertise.
• Strong vision and excellent problem-solving skills, passionate, and have the drive to succeed.
• Entrepreneurial in the style of working and have the energy level to create and lead a group of motivated individuals
• Ability to communicate and influence at high levels with both internal and external stakeholders.
• Proven ability to learn new information rapidly and effectively

Desirable Attributes for this Role

• Immunology, Rheumatology, Transplant, Neurology, Endocrinology, Gastroenterology or other internal medicine specialty Physician board certified or board-eligible
• Experience of working with Market Companies to deliver studies/projects
• Experience of clinical/commercial interface
• Global external awareness within the therapeutic area and global regulatory environment
• Ability to travel nationally and internationally

At AstraZeneca, we trust in the science. Driven by it and united by it, this is the place where great science comes alive. It’s our smart thinking and patience that helps us to push the boundaries of science to deliver life-changing medicines. If you have a true love of science and believe in its potential to redefine the possible, then this is the place for you.

The annual base pay (or hourly rate of compensation) for this position ranges from $309,354 to $464,031.Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, the employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.